Current Understanding of PCSK۹ and Its Relevance to Cancer Prognosis and Immune Therapy: A Review
- سال انتشار: 1403
- محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 19، شماره: 1
- کد COI اختصاصی: JR_IJP-19-1_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 152
نویسندگان
Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
B.Sc. of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
چکیده
The effectiveness of immunotherapy for most cancer patients remains low, with approximately ۱۰–۳۰% of those treated surviving. Thus, much effort is being put into finding new ways to improve immune checkpoint therapy. Our review concludes that the inhibition of proprotein convertase subtilisin/Kexin type ۹ (PCSK۹), which plays a critical role in regulating cholesterol metabolism, can cause T cells to move toward tumors, with increased sensitivity to immune checkpoint therapies.We searched PubMed, NCBI, Scopus, and Google Scholar for the published articles without limitations on publication dates. We used the following terms: “PCSK۹”, “Cancer”, “Immune Checkpoint”, and “Cancer Prognosis” in the title and/or abstract. Our search initially revealed ۶۰۰ records on the subject and stored them in the used databases under EndNote X۸ management software. We selected about ۱۶۱ articles that were carefully read and among them, ۷۶ were included in our research.We concluded that PCSK۹ reduces the number of LDL receptors (LDL-R) on the cell surface, which is linked to its ability to regulate cholesterol levels in the body. Also, we discuss how suppressing PCSK۹ leads to the MHC-۱ accumulation on the surface of cancer cells, which results in T lymphocyte invasion. Finally, we believe that inhibiting PCSK۹ may be an effective strategy for improving cancer immunotherapy.کلیدواژه ها
PCSK۹, Immunotherapy, Cancer, Immune checkpointاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.