Evaluation of the biological activities of chrysin as an importantperspective in the treatment of infectious and cancer diseases

سال انتشار: 1402
محل انتشار: دومین همایش بین المللی زیست شناسی و علوم آزمایشگاهی
کد COI اختصاصی: ZISTCONF02_054
زبان مقاله: انگلیسی
تعداد مشاهده: 195

نویسندگان

Department of Medical Microbiology and Virology, School of Medicine, ZanjanUniversity of Medical Sciences, Zanjan, Iran, Iran.

Bahman Mirzaei

Department of Medical Microbiology and Virology, School of Medicine, ZanjanUniversity of Medical Sciences, Zanjan, Iran, Iran.

Mina Shir Mohammad pour

Arman Taran

Students of laboratory sciences, Zanjan University of Medical Sciences, Zanjan, Iran,Iran.

Maryam Asadi

Students of laboratory sciences, Zanjan University of Medical Sciences, Zanjan, Iran,Iran.

چکیده

Background and Aim: Chrysin, a flavonoid compound found in medicinalplants, honey, and propolis, has potential biological activities that make it animportant perspective in the treatment of infectious and cancer diseases. Theaim of this review study is to evaluate the biological activities of chrysin in thetreatment of infectious and cancer diseases.Material and Methods : The present study is a review study that searchedreputable scientific databases such as PubMed, Google Scholar, Scopus, andWeb of Science from ۲۰۰۰ to ۲۰۲۳ using keywords such as Antimicrobial,Antifungal, chrysin, Anticancer, Antioxidants, and Infectious diseases. Theresearchers examined ۲۵ articles to determine the biological activities ofchrysin.Results: Chrysin has high inhibitory or lethal activities on gram-positive andgram-negative bacteria, including Staphylococcus aureus, Escherichia coli,Pseudomonas aeruginosa, Bacillus subtilis, and Enterococcus faeces. It also hasanti-biofilm effects and antifungal effects on strains such as Aspergillus nigerand Candida albicans. Chrysin also has anticancer effects on various cancers,including colorectal cancer, pancreatic cancer, breast cancer, and MCF-۷cancer, which have been confirmed in vitro and in vivo.Conclusion: Chrysin has potential as an important therapeutic option in thetreatment of infectious and cancer diseases. Its high antimicrobial andanticancer activities, combined with its low toxicity in nanoparticle form, make it a promising candidate for further clinical trials. The production of anti-microbial and anti-cancer drugs from natural substances, such as chrysin, is a valuable contribution to the field of medicine.

کلیدواژه ها

Chrysin, Antimicrobial, Anticancer, Infectious diseases

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