Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats
- سال انتشار: 1402
- محل انتشار: علوم اعصاب کاسپین، دوره: 10، شماره: 1
- کد COI اختصاصی: JR_CJNS-10-1_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 188
نویسندگان
Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Department of Anatomical Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Department of Anatomical Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
چکیده
Background: Gum arabic (GA) contains anti-oxidant and anti-inflammatory compounds and protects tissues. Objectives: The purpose of the present study was to investigate the protective effect of GA on the spinal cord’s motor neurons after ischemia-reperfusion (I-R) injury. Materials & Methods: Thirty-five male rats (Sprague-Dawley) were randomly divided into five groups: Intact, sham surgery, control (۴ mL/kg distilled water+I/R), low-dose gum arabic (GA ۱ g/kg+I-R), and high-dose gum arabic (GA ۴ g/kg+I-R). In the experimental groups, oral gavages’ treatment was performed for ۲۱ days before surgery. Three days after I-R, the rats were evaluated for neurological function, biochemical, and histological analysis. Results: The mean motor deficit index (MDI) in the GA groups versus the control group was significantly lower (P< ۰.۰۱). About ۷۲ hours after I-R, the mean plasma level of superoxide dismutase and total anti-oxidant capacity in the GA ۴ g/kg group were higher than the control group (P< ۰.۰۵). However, there was no significant difference in the plasma level of catalase between the GA ۴ g/kg and the control groups (P< ۰.۰۵). Approximately ۶۷% of the motor neurons were destroyed in the control group, while this ratio was about ۱۸% in the GA ۴ g/kg group. Conclusion: This study showed that GA (۴ g/kg) protects the motor neurons of the spinal cord against ischemia-reperfusion injury.کلیدواژه ها
Gum arabic, Ischemia, Reperfusion, Spinal cord, Ratsاطلاعات بیشتر در مورد COI
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