The Effect of Ultrasound on Acceleration of Peripheral Nerve Injury
- سال انتشار: 1391
- محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 2، شماره: 4
- کد COI اختصاصی: JR_JBPE-2-4_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 178
نویسندگان
Department of Bioelectrical Engineering, Iran University of Science and Technology, Tehran, Iran
Department of Bioelectrical Engineering, Iran University of Science and Technology, Tehran, Iran
Department of Physical Medicine and Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
Department of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran
Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran
چکیده
Background: Many people suffer from nerve injury. The time consuming nature of the treatments makes the condition worse. Therefore, finding a way to accelerate the process of nerve repair is very important.Objective: To determine the effect of ultrasound on the acceleration of crushed peripheral nerve regeneration.Methods: The experimental model included crushed rat’s sciatic nerve. ۴۰ rats were categorized into control and test groups. We used functional and electrophysiological tests to measure the amount of nerve regeneration. We extracted SFI from rats paw print for functional test and measured CMAP wave amplitude for electrophysiological test. After testing ۳ types of ultrasound radiation parameters, we selected the best parameters. Ultrasound radiation in test group had the intensity of ۰.۲ W/cm۲ and frequency of ۳ MHz. It was applied ۳ days per week for ۲ min each time starting ۷۲ h after the injury. Control group just received sham expose.Results: During the treatment period, both SFI and CMAP amplitude was significantly higher in test group than in control groups (p< ۰.۰۵).Conclusion: We found that ultrasound accelerates injured peripheral nerve regeneration. In addition, type of injury can be assessed according to changes in CMAP amplitude during the treatment period.کلیدواژه ها
Sciatic nerve, Crush injury, Nerve regeneration, SFI, CMAPاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.