Fabrication and Evaluation of Properties of ۳D Scaffolds Based on Polyethylene Oxide and Poly (Glycerol Sebacic Acid) for Use in Skin Tissue Engineering
- سال انتشار: 1402
- محل انتشار: دهمین کنگره بین المللی زخم و ترمیم بافت
- کد COI اختصاصی: WTRMED10_070
- زبان مقاله: انگلیسی
- تعداد مشاهده: 49
نویسندگان
PhD Student, Department of Tissue engineering, School of Medicine, Fasa University of Medical Sciences (FUMS), Fasa, Iran
Assistant Professor, Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences (FUMS), ,Fasa, Iran
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box ۱۹۹۴۵-۵۴۶, Tehran, Iran
Assistant Professor, Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences (FUMS), ,Fasa, Iran
Assistant Professor, Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences (FUMS), ,Fasa, Iran
Assistant Professor, Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences (FUMS), ,Fasa, Iran
چکیده
The skin of the largest organ is the first protective barrier and the most vulnerable organ to injury, which after injury can partially restore its integrity and function. However, in some cases, these defects are too severe for spontaneous repair. The skin tissue engineering approach creates practical alternatives to treat skin injuries and diseases. An approach to achieving this goal is to use ۳D scaffolding that mimics the structure and function of native skin tissue. This scaffolding should support the growth of new tissue and provide suitable living space for Migration and cell growth for host cells. Poly (glycerol sebacate) (PGS) is one of several polymer biomaterials that have recently been used in various applications. PGS is made up of two natural components, both of which are found in the body. Glycerol is the primary building block for lipids and sebaceous acid a metabolic intermediate in the oxidation of ω fatty acids. Hence PGS is a rigid, biodegradable, biocompatible elastomer, which through the poly-condensation process leads to the creation of a three-dimensional network of random coils with hydroxyl groups attached to the spine of PGS. The two precursors are also inexpensive and have FDA approval. The chemical and mechanical properties of PGS and degradation behavior are determined by synthesis parameters that enable the adjustable degree of Ester. PGS shows limited water absorption capacity. To address these limitations, PGS can be physically and chemically modified to improve its properties. PEO is a water-friendly and biocompatible polymer. Our aim in this study is to investigate porous PGs and PEO scaffolding to modify the properties of PGS water absorption capacity by changing the molar ratio of PGS to PEO. The results showed that with the addition of PEO, the number of hydroxyl groups in the polymer network and the transverse binding density decreased. The morphology of the sample surface has also changed with the increase in the weight percentage of PEO, creating a porous and interconnected structure. The integration of hydrophilic PEO chains has led to increased water absorption by the polymer network and increased degradation rate with increased PEO concentration, indicating the PGS degradation rate regulation with this material. Scaffolding showed elastomeric properties. They also support cell proliferation and can therefore be used for a range of tissue engineering applications.کلیدواژه ها
Poly (glycerol sebacic acid), polyethylene oxide, biocompatibility, salt washing, skin tissue engineeringاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.