Investigation of Combination Effect Between ۶ MV X-Ray Radiation and Polyglycerol Coated Superparamagnetic Iron Oxide Nanoparticles on U۸۷-MG Cancer Cells
- سال انتشار: 1399
- محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 10، شماره: 1
- کد COI اختصاصی: JR_JBPE-10-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 64
نویسندگان
PhD, Department of Radiology Technology, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
PhD, Department of Radiologic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
PhD, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
PhD, Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran
PhD, Department of Radiology Technology, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
PhD, Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
چکیده
Background: Radiosensitization using nanoparticles is proposed as a novel strategy for treatment of different cancers. Superparamagnetic iron oxide nanoparticles (SPIONs) have been reported to enhance effects of radiotherapy in several researches. Objective: The objective of this research is to investigate the radiosensitization properties of polyglycerol coated SPIONs (PG-SPIONs) on U۸۷-MG cancer cells. Material and Methods: In this experimental study, polyglycerol coated SPIONs were synthesized by thermal decomposition method and characterized by FTIR, TEM and VSM analysis. Cellular uptake of nanoparticles by cells was examined via AAS. Cytotoxicity and radiosensitization of nanoparticles in combination with radiation were evaluated by MTT and colony assay, respectively. Results: Mean size of nanoparticles was ۱۷.۹±۲.۸۵ nm. FTIR verified SPIONs coating by Polyglycerol and VSM showed that they have superparamagnetic behaviour. Viability significantly (P < ۰.۰۰۱) decreased at concentrations above ۱۰۰µg/ml for SPIONs but not for PG-SPIONs (P > ۰.۰۵). Dose verification results by TLD for doses of ۲ and ۴ Gy were ۲±۰.۱۹ and ۴±۰.۱۲ Gy respectively. The combination index for all situations was less than ۱ and the effect is antagonism. Conclusion: However, PG-SPIONs combination with ۶ MV X-ray reduced survival of U۸۷-MG cells compared to radiation alone but the effect is antagonism.کلیدواژه ها
Polyglycerol, X-rays, Magnetite Nanoparticlesاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.