Phototherapy and Sonotherapy of Melanoma Cancer Cells Using Nanoparticles of Selenium-Polyethylene Glycol-Curcumin as a Dual-Mode Sensitizer
- سال انتشار: 1399
- محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 10، شماره: 5
- کد COI اختصاصی: JR_JBPE-10-5_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 65
نویسندگان
MSc, Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
MSc, Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
MSc, Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
PhD, Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: As an alternative form of cancer therapy, photothermal therapy (PTT) and sonodynamic therapy (SDT) using nanomaterials are in development. Nanomaterials can act as energy absorber as well as anti-cancer agent. Objective: In this study, the effects of laser and ultrasound irradiation with Se-PEG-Cur nanoparticles were investigated on melanoma cancer.Material and Methods: In this experimental study, nanoparticles of selenium-polyethylene glycol-curcumin (Se-PEG-Cur) were synthesized, and their UV-vis absorption, particle size, zeta potential and photothermal conversion efficiency were determined. Se-PEG-Cur was then introduced as a novel ۸۰۸-nm laser light absorbing agent as well as ultrasound (US) wave for treatment of C۵۴۰ (B۱۶/F۱۰) cancer cells. Also, ROS generation in C۵۴۰ (B۱۶/F۱۰) cancer cells was measured upon PTT and SDT using Se-PEG-Cur. Results: Mean size, zeta potential and photothermal conversion efficiency of Se-PEG-Cur were obtained as ~۳۰۰ nm, ۴۲.۷ mV and ۱۶.۷%, respectively. Cell viability upon irradiation of the laser light or US waves with ۱۰۰ µg mL-۱ Se-PEG-Cur were decreased to ۳۳.۹ and ۲۲.۹%, respectively. Conclusion: Intracellular ROS detection indicated that dual PTT and SDT in the presence of Se-PEG-Cur induced the highest ROS production. Se-PEG-Cur was therefore introduced as an absorbing agent of both laser light and US waves for cancer treatment.کلیدواژه ها
Hyperthermia, Skin Cancer, Diode Laser, Ultrasound, Nanomedicine, Reactive Oxygen Species, Cell Survivalاطلاعات بیشتر در مورد COI
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