Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter
- سال انتشار: 1398
- محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 9، شماره: 2
- کد COI اختصاصی: JR_JBPE-9-2_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 50
نویسندگان
Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
Pharmaceutical Department, Food & Drug Laboratory Research Center, Food & Drug Organization (FDO), Tehran, Iran.
Nanobiomaterials Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran ۱۴۱۷۶۱۴۱۱, Iran
Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
Pharmaceutical Department, Food & Drug Laboratory Research Center, Food & Drug Organization (FDO), Tehran, Iran.
چکیده
Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy. Many in-vivo and in-vitro investigations have indicated that gold nanoparticles (AuNPs) can significantly increase tumor injuries in low kilovoltage radiotherapy. While deep-lying tumors require much higher energy levels with greater penetration power, and investigations carried out in megavoltage energy range show contradictory results. Objective: In this study, we quantitatively assess and compare dose enhancement factors (DEFs) obtained through AuNPs under radiation of Cobalt-۶۰ source (۱.۲۵MeV) versus Iridium-۱۹۲ source (۳۸۰ KeV) using MAGAT gel dosimeter. Material and Methods: MAGAT polymer gel in both pure and combined with ۰.۲ mM AuNPs was synthesized. In order to quantify the effect of energy on DEF, irradiation was carried out by Co-۶۰ external radiotherapy and Ir-۱۹۲ internal radiotherapy. Finally, readings of irradiated and non-irradiated gels were performed by MR imaging. Results: The radiation-induced R۲ (۱/T۲) changes of the gel tubes doped with AuNPs compared to control samples, upon irradiation of beams released by Ir-۱۹۲ source showed a significant dose enhancement (۱۵.۳۱% ±۰.۳۰) relative to the Co-۶۰ external radiotherapy (۵.۸۵% ±۰.۱۴). Conclusion: This preliminary study suggests the feasibility of using AuNPs in radiation therapy (RT), especially in low-energy sources of brachytherapy. In addition, MAGAT polymer gel, as a powerful dosimeter, could be used for ۳D visualization of radiation dose distribution of AuNPs in radiotherapy.کلیدواژه ها
Brachytherapy, Dose Enhancer, External Radiotherapy, Gel Dosimetry, Nanotechnologyاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.