Magnetic Targeting of Magneto-Plasmonic Nanoparticles and Their Effects on Temperature Profile of NIR Laser Irradiated to CT۲۶ Tumor in BALB/C Mice
- سال انتشار: 1400
- محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 11، شماره: 3
- کد COI اختصاصی: JR_JBPE-11-3_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 52
نویسندگان
MSc, Radiation Research Center, Allied Medical Sciences School, AJA University of Medical Sciences, Tehran, Iran
PhD, Department of Medical Physics, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
PhD, Radiation Research Center, Allied Medical Sciences School, AJA University of Medical Sciences, Tehran, Iran
چکیده
Background: Photothermal therapy (PTT) is a promising method in the field of cancer hyperthermia. In this method, interaction between laser light and photosensitizer material, such as plasmonic nanoparticles, leads into a localized heating. Recent efforts in the area of PTT aim to exploit targeting strategies for preferential accumulation of plasmonic nanoparticles within the tumor. Objective: To investigate the impact of magneto-plasmonic (Au@Fe۲O۳ ) nanoparticles on temperature profile of CT۲۶ tumor, bearing mice were irradiated by NIR laser.Material and Methods: In this in vivo study, Au@Fe۲O۳ NPs were injected intraperitoneally to Balb/c mice bearing CT۲۶ colorectal tumor. Immediately after injection, a magnet (magnetic field strength of ۰.۴ Tesla) was placed on the tumor site for ۶ hours in order to concentrate nanoparticles inside the tumor. In the next step, the tumors were exposed with NIR laser source (۸۰۸ nm; ۲ W/cm۲; ۵ min). Results: Tumor temperature without magnetic targeting increased ~۷ ± ۰.۹ °C after NIR irradiation, whereas the tumors in magnetic targeted group experienced a temperature rise of ~۱۲ ± ۱.۴ °C. Conclusion: It is concluded that Au@Fe۲O۳ nanoparticle is a good candidate for therapeutic nanostructure in cancer photothermal therapy.کلیدواژه ها
cancer, Nanomedicine, Nanoparticles, Laser Therapy, Hyperthermiaاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.