The CB۱ cannabinoid receptors involvement in anti-epileptic effect of safranal on penicillin-induced epileptiform activity in rats
- سال انتشار: 1403
- محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 15، شماره: 1
- کد COI اختصاصی: JR_VRFAN-15-1_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 51
نویسندگان
PhD Candidate, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
چکیده
Neuroprotective effects for natural products are supported by several studies. In this regard, safranal, a constitute of saffron, has the potential to exert beneficial effects in neuro-logical disorders such as Parkinson's disease, epilepsy, stroke, multiple sclerosis and Alzheimer's disease. Here, we investigated the effect of safranal on penicillin-induced epileptiform activity. Also, the effects of intracerebroventricular (ICV) microinjection of AM۲۵۱ as a CB۱-cannabinoid receptors antagonist to clarify the possible mechanism of safranal were evaluated. Epileptiform activity was induced by intra-cortical administration of penicillin (۳۰۰ IU, ۱.۵۰ μL) in urethane-anesthetized rats. Electrocorticographic recordings were used to analyze the frequency and amplitude of spike waves. Intraperitoneal injections of safranal at doses of ۱.۰۰ and ۴.۰۰ mg kg-۱ significantly reduced both the number and amplitude of spike waves. The ICV microinjection of AM۲۵۱ (۰.۵۰ μg ۲.۰۰ μL-۱) significantly increased the frequency and amplitude of spike waves. In addition, the anti-epileptic effect induced by administration of safranal at a dose of ۴.۰۰ mg kg-۱ was partially prevented by ICV microinjection of ۰.۵۰ μg ۲.۰۰ μL-۱ of AM۲۵۱. The results showed anti-epileptiform activities for safranal. Central CB۱ cannabinergic receptors might be involved in the anti-epileptiform activity of safranal.کلیدواژه ها
AM۲۵۱, epileptiform activity, Penicillin, Rat, Safranalاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.