Myeloproliferative disorders and its associated mutations

  • سال انتشار: 1393
  • محل انتشار: مجله تحقیق در پزشکی مولکولی، دوره: 2، شماره: 4
  • کد COI اختصاصی: JR_REMJ-2-4_002
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 61
دانلود فایل این مقاله

نویسندگان

Kaveh Tari

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Reza Yarahmadi

Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran

Amir Tabatabaei

Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran

Fakhredin Saba

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Saeid Abroun

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Amir Atashi

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Masoud Soleimani

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

چکیده

Myeloproliferative Neoplasm (MPN) are a clonal disorder in hematopoietic stem cells (HSC). MPN is categorized to ۸ subclasses, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocytopenia (ET), primary myelofibrosis (PMF), systematic mastositosis (SM), chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia (CNL), and unclassified myelofibrosis disorders (UMPN). It usually occurs in ۵th to ۷th decade of life. However, CNL and ET have been observed in children. A lot of mutations have been identified in these disorders that Jak۲V۶۱۷F is the most important mutation. Moreover, several somatic mutations other than JAK۲V۶۱۷F in MPN patients have been reported. Such mutations include MPL, TET۲, ASXL۱, IDH۱, IDH۲, CBL, LNK, IKZF, and EZH۲ from precursor stem cells. The role of mutations mentioned is not clear in pathogenesis of this disease. Hence, in this study, mutations in different stages of myeloproliferative disorders have been reviewed.

کلیدواژه ها

MPN, Hematopoietic stem cells, Mutation

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.