Oleuropein Attenuates Deltamethrin-induced Apoptosis in Rat Cerebellar Purkinje Neurons
- سال انتشار: 1394
- محل انتشار: مجله تحقیق در پزشکی مولکولی، دوره: 3، شماره: 4
- کد COI اختصاصی: JR_REMJ-3-4_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 109
نویسندگان
Molecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. This study aimed at determining the DM toxicity and anti-apoptotic effect of OE pretreatment in cerebellar Purkinje neurons. Materials and Methods: Rats were randomly divided into four groups as follow: DM treated group (۱۲.۵ mg/kg single dose), OE treated group (۲۰ mg/kg per day), DM plus OE treated group, and vehicle group. Sections of cerebellum were taken ۲۴ hours after deltamethrin injection and studied for histopathological and immunohistochemistry assessments. Results: Further characteristics of degeneration in Purkinje neurons were observed in DM group compared with DM plus OE group. Compared with DM group (۹.۵۶±۱.۶۹), the positive staining for Bax in Purkinje neurones decreased in DM plus OE group (۲.۹۹±۰.۵۰) but upper than OE (۰.۷۲±۰.۱۵) and vehicle (۰.۵۷±۰.۰۳) groups. Compared with DM group (۰.۵۰±۰.۰۵), the positive staining for Bcl-۲ in Purkinje neurons increased in DM plus OE group (۳.۲۹±۰.۱۸) but lower than OE (۴.۳۸±۰.۸۰) and vehicle (۵.۸۷±۱.۹۳) groups. Conclusions: Our results suggest that DM induces apoptosis in Purkinje cells which is subsided by oleuropein.کلیدواژه ها
Deltamethrin, Oleuropein, Purkinje, Apoptosisاطلاعات بیشتر در مورد COI
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