Vaccine Design Based on Live Attenuated Cells of Toxoplasma gondii: a Review

  • سال انتشار: 1396
  • محل انتشار: مجله تحقیق در پزشکی مولکولی، دوره: 5، شماره: 4
  • کد COI اختصاصی: JR_REMJ-5-4_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 42
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نویسندگان

Kourosh Cheraghipour

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Mohammad Ali Mohaghegh

Department of Laboratory Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Omid Mardanshah

Department of Laboratory Sciences, Sirjan Faculty of Medical Sciences, Sirjan, Iran

Javad Koshki

Lorestan Provincial Veterinary Service, Khorramabad, Iran

Kobra Moradpour

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Nader Pestechian

Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Javad Akhtari

Department of Physiology and Pharmacology, Immunogenetics Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Abdolrazagh Marzban

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

چکیده

Toxoplasma gondii is well- known as a common parasite with high proliferative activity in the nucleated cells. This parasite has infected nearly one third of the people worldwide. Infection can result in chorioretinitis in immunocompetent hosts, encephalitis in HIV/AIDS positive patients and abortion and neonatal loss in congenital toxoplasmosis. Development of vaccines for toxoplasmosis infection is very important for decreasing infection transmission routes of the disease in various host species in the world. Live attenuated vaccines are closest to a natural infection; therefore, they are good rescuers of the immune system and often create lifelong immunity with only one or two doses. In this study, the researchers reviewed the current status in the development of live attenuated vaccines on Toxoplasma infection.

کلیدواژه ها

Toxoplasma gondii, vaccine, Tachyzoite, Bradyzoite

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