Zahra Tahmasebi Fard - Department of Cell and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Fatemeh Rouhollah - Department of Cell and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Nahid Nafisi - Surgery Department, Iran University of Medical Science, Tehran, Iran

Background: Breast cancer is a hormone-dependent malignancy that is associated with estrogen and progesterone interactions. The liver is the most important organ to be affected by the metastasis of breast cancer, which causes functional impairment. We compared levels of obesity, ۱۷β-estradiol, and secreted proteins in postmenopausal women with breast cancer but without hepatic symptoms to those in healthy postmenopausal women. Materials and methods :We recruited ۱۰۵ postmenopausal women with breast cancer but without any clinical hepatic symptoms based on a physician’s diagnosis, and ۱۰۵ healthy postmenopausal women. After taking blood samples, we separated the serum and determined the levels of alanine aminotransferase (ALT), enzyme aspartate aminotransferase (AST), sex hormone-binding globulin (SHBG), and ۱۷β-estradiol using an enzyme-linked immunosorbent assay (ELISA). The results were statistically analyzed using SPSS. Results: The mean ages of the subjects in the cancer and control groups were ۶۰.۸۸ ± ۰.۸۵ and ۵۵.۵۶ ± ۰.۸۱ years, respectively. The exception ages (p=۰.۰۰۲), body mass index (BMI) values (p=۰.۰۳۳), serum glutamic oxaloacetic transaminase (SGOT) levels/AST levels (p=۳.۱*۱۰-۴), serum glutamic pyruvic transaminase (SGPT) levels/ALT levels(p=۰.۰۰۱), SHBG levels(p=۰.۰۱۴), and ۱۷β-estradiol levels(p=۰.۰۰۳) in the serum differed significantly between the groups. Moreover, the mean serum ۱۷β-estradiol (E۲) levels and weights were higher in the cancer group than in the control group. Nevertheless, the mean serum levels of synthetic liver enzymes (SHBG, ALT, and AST) were lower in the cancer group than in the control group. Conclusion: In general, the postmenopausal cancer patients had higher serum estrogen levels and BMIs than their healthy counterparts. Furthermore, the levels of liver enzymes apparently decreased in the cancer group, probably owing to liver malfunction.

Breast cancer, SGOT, SGPT, SHBG, ۱۷β-estradiol