Prognostic Significance of Notch-۴, SATB-۲, and Glutaminase-۱ in Colorectal Adenocarcinoma
- سال انتشار: 1403
- محل انتشار: مجله سرطان خاورمیانه، دوره: 15، شماره: 1
- کد COI اختصاصی: JR_MISJ-15-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 79
نویسندگان
Pathology Department, Medicine College, Zagazig University, Egypt
Department of Clinical Oncology and Nuclear Medicine, Medicine College, Zagazig University, Egypt
Department of Clinical Oncology and Nuclear Medicine, Medicine College, Zagazig University, Egypt
Pathology Department, Medicine College, Zagazig University, Egypt
چکیده
Background: Neurogenic locus notch homology ۴ (Notch-۴) is crucial in maintaining stem cells. Special AT-rich sequence-binding protein ۲ (SATB-۲) is a transcription factor that binds to the nuclear matrix and serves various functions, including brain development. Glutaminase-۱ (GLS-۱) plays a pivotal role in cancer cell metabolism, growth, and proliferation. This study aims to assess the expression of these markers in colorectal cancer, establishing correlations with clinicopathological characteristics and patient survival.Method: In this retrospective study, we retrieved and analyzed ۶۸ formalin-fixed, paraffin-embedded blocks of primary colorectal adenocarcinoma, not otherwise specified cases, and adjacent normal mucosa. Notch-۴, SATB-۲ and GLS-۱ expressions were analyzed using immunohistochemistry at the Zagazig School of Medicine, Egypt.Results: High expressions of Notch-۴ and GLS-۱ and low expression of SATB-۲ were observed in colonic adenocarcinoma but not in adjacent non-neoplastic mucosa (P < ۰.۰۰۱). High expressions of Notch-۴ and GLS-۱, along with low expression of SATB-۲, were associated with a higher tumor grade, advanced stage (P < ۰.۰۰۱), lymphovascular invasion, lymph node metastasis, and poor disease-free survival and overall survival rates (P < ۰.۰۰۱).Conclusion: High expression of Notch-۴ and GLS-۱ is correlated with a poor prognosis in colorectal cancer, while high expression of SATB-۲ is associated with a favorable prognosis for colorectal carcinoma. These markers can aid in predicting tumor prognosis and guiding targeted therapy for colorectal carcinoma.کلیدواژه ها
Colorectal neoplasms, Immunohistochemistry, Prognosisاطلاعات بیشتر در مورد COI
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