Leli Avesta - Department of Cardiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Hossein Doustkami - Department of Cardiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Bijan Zamani - Department of Cardiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Afshin Nejati - Department of Cardiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Sajad Mousavy - School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Mohammad Reza Aslani - Lung Diseases Research Center, School of Medicine, Ardabil University of Medical Sciences, Ardabil AND Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

BACKGROUND: Elevated serum visfatin levels have been reported in some chronic inflammatory diseases such as cardiovascular diseases (CVDs) and rheumatoid arthritis. The purpose of the present study was to investigate the correlation between visfatin and interleukin-۶ (IL-۶) and anthropometric, angiographic, echocardiographic, and biochemical parameters in patients with acute myocardial infarction (AMI).METHODS: In this case-control study, ۹۰ patients who were candidates for angiography were divided into the following ۳ groups: non-coronary artery disease group (non-CAD; n = ۳۰) with a history of chest pain without angiographic changes, stable angina pectoris group (SAP; n = ۳۰), and AMI group (n = ۳۰). Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects.RESULTS: The mean age of patients in the non-CAD, SAP, and AMI groups was ۶۲.۲۶ ± ۱۳.۲۴, ۶۲.۹۳ ± ۸.۳۵, and ۵۲.۸۳ ± ۱۰.۲۶ years (P < ۰.۰۰۱) respectively. The results showed that the median [interquartile range] of visfatin level was higher in the AMI group [۷ (۶.۳۰-۹.۳۰), pg/ml] compared with the SAP [۵.۸۵ (۵.۲۰-۶.۶۰); P < ۰.۰۰۱] and non-CAD [۵.۲۰ (۳.۳۰-۵.۷۰); P < ۰.۰۰۱] groups. In addition, median [interquartile range] IL-۶ levels were higher in the AMI group [۱۷.۵ (۱۶-۲۱), pg/ml] compared with the SAP [۱۵.۵۰ (۱۴-۱۸); P < ۰.۰۱] and non-CAD [۱۴ (۱۱-۱۷); P < ۰.۰۰۱] groups. Furthermore, there was a positive association between plasma level of visfatin, and epicardial fat thickness (EFT) and the Gensini score in the SAP and AMI patients. The results of multivariate linear regression analysis revealed that white blood cell ‎(WBC) count and IL-۶ were independently associated with plasma visfatin level.CONCLUSION: The current study showed an association between visfatin and EFT in AMI patients. Increased visfatin levels in patients with AMI may contribute to atherosclerosis; however, further studies should be conducted to confirm this finding.

Visfatin, Adipose tissue, Echocardiography, Myocardial Infarction, Angina Pectoris, Coronary Angiography