Evaluation of the Antioxidant Effects of Green Tea (Camellia sinensis) on Male Albino Mice poisoned with Thioacetamide
- سال انتشار: 1394
- محل انتشار: مجله پژوهشی دانشجویی زیست پزشکی طبری، دوره: 0، شماره: 1
- کد COI اختصاصی: JR_TBSRJ-0-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 161
نویسندگان
MSc. Student of Biochemistry, Research & Science Branch, Islamic Azad University of Fars, Iran
PhD. of Animal Physiology, Associate Professor and Faculty Member of Islamic Azad University, Falavarjan Branch, Isfahan, Iran
PhD. of Clinical Biochemistry (Orientation to Cancer), Associate Professor and Faculty Member, Research & Science Branch, Islamic Azad University of Fars, Iran
چکیده
Background & Objectives: Effects of free radicals and reactive oxygen species (ROS) on biological systems have been one of the most important medical concerns. Production of free radicals and ROS is inherent to aerobic life. This study aimed to investigate the antioxidant effects of green tea (camellia sinensis) on male Albino mice poisoned with thioacetamide. Materials and Methods: In this study, thioacetamide was injected intraperitoneally at doses of ۱۰۰ and ۱۵۰ mg/kg. In addition, enzyme activity of catalase (CAT) and glutathione peroxidase (GPx), as well as the concentration of malondialdehyde (MDA) as the main source of antioxidants, were measured in all the study groups. Results: There was a significant increase in the activities of CAT and GPx, while a significant decrease was observed in the level of MDA in the mice receiving combined green tea and thioacetamide compared to the recipients of thioacetamide alone (P< ۰.۰۵). Conclusion: According to the results of this study, the antioxidant properties of green tea are associated with the presence of a polyphenol called catechin in this plant.کلیدواژه ها
Antioxidant, Catalase, Catechin, Free radicals, Glutathione peroxidise, Green tea, Malondialdehyde, Reactive oxygen species, Thioacetamide, چای سبز, رادیکال های آزاد, تیواستامید, کاتالاز, گلوتاتیون پراکسیداز, مالون دی آلدئید, کاتچین و آنت یاکسیدان.اطلاعات بیشتر در مورد COI
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