Z. Darzian Rostami - Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
A. Asghari - Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
A. Jahandideh - Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
P. Mortazavi - Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
A. Akbarzadeh - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Peripheral nerve disorders are the most common neurological problems; therefore, it is important to intervene to treat or stop the resulting side effects. This study aimed to investigate the effect of oat extract on experimental sciatic nerve injury in rats. Totally, ۵۰ adult male rats were divided into five groups (n=۱۰). Group ۱ was exposed to sham condition, and group ۲ was regarded as the control group (nerve injury without treatment). Moreover, groups ۳-۵ were subjected to sciatic nerve injury, and they received oral gavages of the oat extract (۱۰۰, ۲۰۰, and ۴۰۰ mg/kg), respectively. Subsequently, ۲ and ۴ weeks later, the rats were euthanized for pathological evaluation of nerve repair. The results showed an increase in the formation of the perineurium and epineurium dose in the oat-treated groups (۱۰۰, ۲۰۰, and ۴۰۰ mg/kg), compared to the control group after ۲ weeks (p <۰.۰۵). Furthermore, the presence of inflammatory cells in the oat extract-treated groups (۱۰۰, ۲۰۰, and ۴۰۰ mg/kg) decreased, compared to that in the control group after ۲ weeks (p <۰.۰۵). In addition, the swelling of the axon significantly decreased in the oat extract-treated groups (۲۰۰ and ۴۰۰ mg/kg), compared to the control group (p <۰.۰۵). However, the axon dose-dependently increased in oat-treated groups (۱۰۰, ۲۰۰, and ۴۰۰ mg/kg), compared to that in the control group after ۴ weeks (p <۰.۰۵). These results suggest that oat extract has positive effects on sciatic nerve repair in rats.

Oat extract, rat, Sciatic nerve injury