Effects of Toxoplasma gondii on Levels of Interleukin-۵ in Parkinson's Patients

Parkinson's disease (PD) is a psychiatric neurological infection of the focal sensory system and is accepted as a multifactorial disease. Chronic Toxoplasmosis is sometimes associated with the proliferation of bradyzoites in the nervous system. The measurement of interleukin-۵ (IL-۵) as an inflammatory mediator in patients with PD and Toxoplasmosis infection may be helpful in determining the correlation between these diseases. In the present study, ۸۰ examples were collected, including ۳۵ patients diagnosed with idiopathic PD and ۴۵ samples from healthy people from Najaf, Babylon, and Baghdad provinces, Iraq. After measuring the immunoglobulin G (IgG) antibody of Toxoplasma gondii, the level of IL-۵ was evaluated in different groups. Serological examination showed that the IgG antibody of Toxoplasmosis increased (P<۰.۰۵) in people with PD (۶۵.۷۱%). Serum levels of IL-۵ significantly decreased in people with PD. It is noteworthy that comparing serum levels of IL-۵ between two groups of people with and without chronic Toxoplasmosis revealed that there was a significant decrease (P<۰.۰۵) in a concentration of serum IL-۵ in individuals with chronic Toxoplasmosis. The current study confirmed the conceivable association between T. gondii and PD, and further research is recommended to explain the association between PD and Toxoplasmosis.

کلیدواژه ها:

Toxoplasma gondii ، Interleukin-۵ ، Parkinson's disease