I Hussein Naser - Department of Clinical Pharmacy, College of Pharmacy, University of Kerbala, Kerbala, Iraq
N. D Aziz - Department of Clinical Pharmacy, College of Pharmacy, University of Kerbala, Kerbala, Iraq
Z Abed Al-Kareem - Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Kerbala, Iraq

Carbimazole is a widespread drug utilized for treating hyperthyroidism. However, carbimazole usage could be associated with adverse effects such as liver damage and nephritis in rats. At the same time, turmeric, as a medical plant, has many antioxidant effects against liver and kidney toxicity. This study aimed to explore the protective effect of turmeric against carbimazole–induced toxicity in rats. The experiment was carried out on ۲۴ male Wistar rats. They were separated into four groups, each with six animals, as follows: ۱. Control group: represents a healthy animal, and each rat is only given standard food and distilled water for ۳۰ days. ۲. Carbimazole group: drenched orally ۰.۵ mg carbimazole daily for ۳۰ days. ۳. Turmeric group: drenched orally ۱۰۰ mg turmeric powder daily for ۳۰ days. ۴. Carbimazole and turmeric group: drenched orally carbimazole ۰.۵ mg and turmeric ۱۰۰ mg daily for ۳۰ days. The study demonstrated a significant effect of turmeric powder in reducing the toxicity of carbimazole in both the kidney and liver biochemical parameters, in addition to the evidence of histological sections. Turmeric powder has the ability to reduce and prevent renal and hepatic toxicity induced by carbimazole overdose, which gives turmeric medical value.

Carbimazole, Hepatic toxicity, rats, Renal toxicity, Turmeric