Genetic Polymorphisms of NOD۲ and ATG۱۶L۱ in Different Types of Digestive Tract Inflammation

  • سال انتشار: 1402
  • محل انتشار: مجله آرشیو رازی، دوره: 78، شماره: 1
  • کد COI اختصاصی: JR_ARCHRAZI-78-1_059
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 193
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نویسندگان

N Mushtaq Hashim Al-Bderee

Medical Biotechnology Department, College of Biotechnology, Al-Qasim Green University, Babylon Province, Iraq

N Faaz Nassir Al-Saad

Medical Biotechnology Department, College of Biotechnology, Al-Qasim Green University, Babylon Province, Iraq

M Jawad Al-Imari

Department of Medical Laboratory Techniques, Al-Mustaqbal University College, ۵۱۰۰۱ Hillah, Babylon, Iraq

S Mudhaher Habbeb

Medical Biotechnology Department, College of Biotechnology, Al-Qasim Green University, Babylon Province, Iraq

A Mizal Azoz

Medical Biotechnology Department, College of Biotechnology, Al-Qasim Green University, Babylon Province, Iraq

چکیده

Inflammatory bowel diseases (IBD) result from genetic and environmental factors. The two clinical manifestations of inflammatory bowel disease are ulcerative colitis and Crohn's disease (IBD). Numerous studies have demonstrated a link between immune system molecules' single nucleotide polymorphisms (SNPs) and the incidence of IBD. The study aimed to examine the potential impact of the SNPs NOD۲ rs۲۰۶۶۸۴۴ and ATG۱۶L۱ rs۲۲۴۱۸۸۰ in a group sample of Iraqi IBD patients. The AG genotype for rs۲۲۴۱۸۸۰ was associated with an increased risk for CD (P=۰.۱) and a negative association with UC, whereas the AA genotype presents less in CD patients and a negative association with UC (P=۰.۸۹). For this SNP, the G allele was associated with the risk of CD but not for UC. For the rs۲۰۶۶۸۴۴, there were no significant differences for NOD۲ in both CD and UC, and associations between variation and diseases were not observed.

کلیدواژه ها

NOD۲, ATG۱۶L۱, Crohn's Disease, Ulcerative Colitis

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