Combined Effects of ۵۲۸ Hz Sound and X-ray in Peripheral Blood Lymphocytes

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 142

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شناسه ملی سند علمی:

JR_IJMP-15-0_093

تاریخ نمایه سازی: 29 آذر 1402

چکیده مقاله:

Introduction: Radiotherapy is still one of the main options for cancer treatment but it is in association with damage to normal cells as well as the tumor cells. To reduce the injury in normal cells we have evaluated the effect of ۵۲۸ hertz sound after X irradiation in peripheral blood lymphocytes. Materials and Methods: in this study, peripheral blood was obtained from ۲۵ healthy volunteers and blood lymphocytes were separated and divided into ۴ groups: Ι) Control group, П) Radiation group, Ш) Radiation + Sound group ΙV) Sound group. To measure radiation effect on DNA, nuclear (DNA) damage rate was evaluated in all groups by the use of the comet assay. Results: The obtained data revealed that DNA damage rate in radiation group (۱۹۰±۴۵) is significantly higher than control (۱۳۷±۳۲), Sound (۱۵۲±۲۹). But, the difference of DNA damage in control with sound and also radiation+sound groups was not statistically significant.   Conclusion: The results indicating that ۵۲۸ hertz sound could induce radiation damage but when it will be combined with X radiation, the DNA damages of X-rays in peripheral blood lymphocytes is not significantly different with control groups which indicate modulation of DNA damages and addresses the needs for further studies.

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نویسندگان

Afshin Nejadjahantigh

Student Research Committee, Babol University of Medical Sciences, Babol, Iran

Kourosh Ebrahimnejad Gorji

Department of Medical Physics Radiobiology and Radiation Protection, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Ali Shabestani Monfared

Cancer Research Center, Babol University of Medical Sciences, Babol, Iran

Ebrahim Zabihi

Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran

Zeinab Abedian

Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran

Elahe Bakhtiari

Student Research Committee, Babol University of Medical Sciences, Babol, Iran

Sajad Borzoueisileh

Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran