The effect of incorporating the quantitative analysis besides visual assessments of ۱۸F-FDG brain PET images for the localization of epileptogenic zones

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 98

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شناسه ملی سند علمی:

JR_IJMP-15-0_159

تاریخ نمایه سازی: 29 آذر 1402

چکیده مقاله:

Introduction: FDG Brain PET is a valuable paraclinical tool for presurgical assessments of patients suffering from refractory epilepsy. By the widespread accessibility of PET, recognizing the functional lesions has become a current practical method especially in preoperative evaluations of the partial epilepsy disorders. The aim of our study was to assess the impact of quantitative software-aided method in localizing epileptic zones in human brain using ۱۸F-FDG Brain PET scan beside the physician qualitative interpretations. Materials and Methods: The subjects have been selected among patients referred to brain PET imaging who were suffering from refractory epilepsy. Seventeen patients (۹ men, ۸ women ; ۲۵±۱۱ YO) underwent PET scan. Quantitative analysis of brain functional images were applied by the Scenium software which provided statistical color-coded images of Z-scores and standard deviations (۱). We considered Z-scores<-۲ as an abnormal range of brain metabolism. It is worth mentioning that, we categorized the patients based on their MRI investigations to lesional and non-lesional groups. Two physicians presented visual assessments in order to localizing epileptic spots. Also, the kappa index had been calculated as an agreement coefficient via SPSS (V.۱۹.۰) software. Results: In the case of assessing the accordance of lesions’ localization among MRI, EEG, and PET/CT evaluations, the agreement level of EEG versus quantitative and qualitative method were reported ۰.۶۷ and ۰.۱۲, respectively, which were related to non-lesional group. Also, in the lesional category, the kappa indices for quantitative and qualitative analysis against the suspicious lesions on MRI were ۰.۵۶ and ۰.۲۷, respectively Conclusion: Epilepsy disorder has destructive effects on quality of life. Thereby, accurate diagnosis of lesion locations could have a vital impact in order to patients’ treatment, exclusively in refractory epilepsy which might treat through doing the brain’s operation (۲). The foregoing discussion is a confirmation of the supplementary role of quantitative software alongside visual assessments, in order to do pre-surgical evaluations of epileptic positions in human brain via ۱۸F-FDG Brain PET images. Hence, utilizing of quantitative software could be a complementary method together with MRI and EEG procedures to improve the confidence of surgeon about the epileptic spots(۳).

کلیدواژه ها:

Nuclear medicine refractory epilepsy ، pre-operative evaluations ، ۱۸F-FDG Brain PET scan

نویسندگان

Naghme Firouzi

Department of Medical Physics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Parham Geramifar

Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences , Tehran, Iran ,

Ali Asghar Parach

Department of Medical Physics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran