The effect of incorporating the quantitative analysis besides visual assessments of ۱۸F-FDG brain PET images for the localization of epileptogenic zones
محل انتشار: مجله فیزیک پزشکی ایران، دوره: 15، شماره: 0
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 98
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شناسه ملی سند علمی:
JR_IJMP-15-0_159
تاریخ نمایه سازی: 29 آذر 1402
چکیده مقاله:
Introduction: FDG Brain PET is a valuable paraclinical tool for presurgical assessments of patients suffering from refractory epilepsy. By the widespread accessibility of PET, recognizing the functional lesions has become a current practical method especially in preoperative evaluations of the partial epilepsy disorders. The aim of our study was to assess the impact of quantitative software-aided method in localizing epileptic zones in human brain using ۱۸F-FDG Brain PET scan beside the physician qualitative interpretations. Materials and Methods: The subjects have been selected among patients referred to brain PET imaging who were suffering from refractory epilepsy. Seventeen patients (۹ men, ۸ women ; ۲۵±۱۱ YO) underwent PET scan. Quantitative analysis of brain functional images were applied by the Scenium software which provided statistical color-coded images of Z-scores and standard deviations (۱). We considered Z-scores<-۲ as an abnormal range of brain metabolism. It is worth mentioning that, we categorized the patients based on their MRI investigations to lesional and non-lesional groups. Two physicians presented visual assessments in order to localizing epileptic spots. Also, the kappa index had been calculated as an agreement coefficient via SPSS (V.۱۹.۰) software. Results: In the case of assessing the accordance of lesions’ localization among MRI, EEG, and PET/CT evaluations, the agreement level of EEG versus quantitative and qualitative method were reported ۰.۶۷ and ۰.۱۲, respectively, which were related to non-lesional group. Also, in the lesional category, the kappa indices for quantitative and qualitative analysis against the suspicious lesions on MRI were ۰.۵۶ and ۰.۲۷, respectively Conclusion: Epilepsy disorder has destructive effects on quality of life. Thereby, accurate diagnosis of lesion locations could have a vital impact in order to patients’ treatment, exclusively in refractory epilepsy which might treat through doing the brain’s operation (۲). The foregoing discussion is a confirmation of the supplementary role of quantitative software alongside visual assessments, in order to do pre-surgical evaluations of epileptic positions in human brain via ۱۸F-FDG Brain PET images. Hence, utilizing of quantitative software could be a complementary method together with MRI and EEG procedures to improve the confidence of surgeon about the epileptic spots(۳).
کلیدواژه ها:
نویسندگان
Naghme Firouzi
Department of Medical Physics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Parham Geramifar
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences , Tehran, Iran ,
Ali Asghar Parach
Department of Medical Physics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran