Study of multifunctional PLGA-SPION nanoparticles loaded with Gemcitabine as radiosensitizer

  • سال انتشار: 1397
  • محل انتشار: مجله فیزیک پزشکی ایران، دوره: 15، شماره: 0
  • کد COI اختصاصی: JR_IJMP-15-0_415
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 47
دانلود فایل این مقاله

نویسندگان

Nima Hamzian

Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Maryam Hashemi

Nanotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.

Mahdi Ghorbani

Biomedical Engineering and Medical Physics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mohammad Ramezani

Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohammad Hossein Bahreyni Toosi

Medical Physics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

چکیده

Abstract This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously into poly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system. The physicochemical characteristics of the nanoparticles (NPs) were studied. The dose enhancement ratio (DER) of various treatment groups was calculated and compared using human breast cancer cell line (MCF-۷). The DER for PLGA-SPION-Gem was the highest at ۱ Gy ۶۰Co (۳.۱۸). Cumulative effect from simultaneous use of two radiosensitizer (Gem and SPIONs) was observed. Thus, we have successfully developed PLGA NPs loaded with gemcitabine and SPION as a radiosensitizer system which potentially could be used in radiotherapy.

کلیدواژه ها

Multifunctional drug delivery system, SPION-PLGA, Gemcitabine, Radiotherapy, Radiosensitizer

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.