Development of electrochemical sensor based on carbon paste electrode modified with ZnO nanoparticles for determination of chlorpheniramine maleate
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 106
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شناسه ملی سند علمی:
JR_AMECJ-4-1_001
تاریخ نمایه سازی: 14 آذر 1402
چکیده مقاله:
Zinc oxide (ZnO) nanoparticles with an average size of ۶۰ nm have
been successfully prepared by microwave irradiation. Carbon paste
electrode (CPE) was modified with ZnO nanoparticles and used for
the electrochemical oxidation of chlorpheniramine maleate (CPM).
Cyclic voltammetry (CV) study of the modified electrode indicated
that the oxidation potential shifted towards a lower potential by
approximately ۱۰۶ mV and the peak current was enhanced by ۲ fold
in comparison to the bare CPE (ZnO/CPE-CV). The electrochemical
behaviour was further described by characterization studies of scan
rate, pH and concentration of CPM. Under the optimal conditions
the peak current was proportional to CPM concentration in the
range of ۸.۰ ×۱۰-۷ to ۱.۰ × ۱۰-۳ mol L-۱ with a detection limit of ۵.۰
× ۱۰-۷ mol L-۱ by differential pulse voltammetry (DPV). The peak
current of CPM is linear in the concentration range of ۰.۸ - ۱۰۰۰
μM (R۲=۰.۹۹۸). The ZnO/CPE has a good reproducibility and high
stability for the determination of CPM using this electrode. The
proposed method was successfully applied to the determination of
CPM in pharmaceutical samples. In addition, the important analytical
parameters were compared with other methods which show that ZnO/
CPE-CV procedure are comparable to recently reported methods.
کلیدواژه ها:
نویسندگان
Hamidxeh Asadollahzadeh
Department of Chemistry, Faculty of Science, Kerman branch, Islamic Azad University, Kerman, Iran, P. O. Box ۷۶۳۵۱۳۱۱۶۷, Kerman, Iran