The effect of nanochitosans particles on Candida biofilm formation
- سال انتشار: 1395
- محل انتشار: سرطان معده، دوره: 2، شماره: 2
- کد COI اختصاصی: JR_CUMM-2-2_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 58
نویسندگان
Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Department of Prosthodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background and Purpose: In people wearing dentures, the growth of various Candida species under the prosthesis leads to the formation of biofilm, which can play the role of a reservoir for Candida and other kinds of microbes. Since nano-chitosan particles can cause lasting antimicrobial activity, a more recent approach that utilizes acrylic resins with nano-chitosan particles is proposed. Therefore, we aimed to study the inhibitory effect of nano-chitosan particles on the biofilm formation of Candida species in acrylic resins. Materials and Methods: In this analytical in-vitro study, acrylic resins with nano-chitosan particles with concentrations of ۰, ۱%, ۵%, and ۱۰% were put adjacent to the suspension of Candida cells isolated from the individuals’ mouth and biofilm formation on resins was measured and compared. Finally, the data were analyzed using Kruskal-Wallis and Chi-square tests. Results:The observed differences between unmodified acrylic resin (control) and acrylic resin with nano-chitosan particles in terms of biofilm formation were significant (p < ۰.۰۵), but no significant difference was found in the formation of biofilm species on resins. Conclusion: Biofilm formation of Candida species depends on acrylic resin type, in a way that by adding nano-chitosan particles to acrylic resins, biofilm formation of Candida species was significantly reduced. To decrease the organization of biofilm and denture stomatitis, the use of acrylics with nano-chitosan particles in producing dentures is recommended.کلیدواژه ها
Acrylic resins, Biofilm, Candida species, Denture, Nano-chitosan Particlesاطلاعات بیشتر در مورد COI
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