Emergence of Azoles Resistance Candida species in Iranian AIDS defined patients with oropharyngeal candidiasis

  • سال انتشار: 1394
  • محل انتشار: سرطان معده، دوره: 1، شماره: 3
  • کد COI اختصاصی: JR_CUMM-1-3_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 66
دانلود فایل این مقاله

نویسندگان

Farzad Katiraee

Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Fardis Teifoori

Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy and laboratory of Parasitology and Allergy, Lascaray Research Center, University of the Basque Country, Vitoria, Spain

Mino Soltani

Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

چکیده

Background and Purpose: Oropharyngeal candidiasis (OPC) and antifungal drug resistance are major health concerns in patients with human immunodeficiency virus (HIV). The increased reports of antifungal resistance and expanding drug therapy options prompted the determination of antifungal susceptibility profile. The present study was performed to determine the antifungal susceptibility of Candida species isolated from AIDS patients with OPC in Iran. Materials and Methods: In total, ۱۰۰ Candida isolates from the oral cavity of patients with OPC (TCD۴ < ۲۰۰ cells/&muL) were obtained and cultured on CHROMagar and Sabouraud’s dextrose agar. All isolates were identified according to the assimilation profile, colony color and other conventional methods. Broth microdilution of antifungal drugs was carried out, according to the methods described in M۲۷-S۴ and M۴۴-A guidelines by the Clinical and Laboratory Standards Institute (CLSI). Results: Among ۶۰ Candida albicans (C. albicans) strains, ۵۶.۷% were resistant to fluconazole, while ۳۸.۳% were resistant to ketoconazole and clotrimazole. The resistance of C. albicans isolates against polyene antifungals including amphotericin B was scarce (۱.۷%). Based on the results, ۵۲.۲% of C. glabrata strains were resistant to fluconazole, while ۴۷.۸% and ۳۰.۴% of these isolates were resistant to ketoconazole and clotrimazole, respectively. All Candida isolates were susceptible to nystatin and caspofungin. Conclusion: Based on the findings, it can be concluded that screening of resistant Candida isolates by disk diffusion or broth dilution method is essential for the surveillance and prevention of antifungal resistance in patient management. Although nystatin is widely used in clinical practice for HIV patients in Iran, no evidence of enhanced resistance against this agent was found on the other hand, resistance to azole antifungals, particularly fluconazole, increased. Considering the lack of resistance to caspofungin, administration of this agent is suggested for the treatment of OPC in AIDS patients.

کلیدواژه ها

Azole resistance, Candida species, Orpharyngeal candidiasis

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.