Microsatellite Genotyping of Candida parapsilosis Clinical Isolates
- سال انتشار: 1396
- محل انتشار: سرطان معده، دوره: 3، شماره: 4
- کد COI اختصاصی: JR_CUMM-3-4_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 62
نویسندگان
Department of Medical Mycology/Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Department of Medical Mycology and Parasitology, Tehran University of Medical Sciences, Tehran, Iran
Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, Netherlands
Department of Medical Mycology and Parasitology, Tehran University of Medical Sciences, Tehran, Iran
Department of Medical Mycology and Parasitology, Tehran University of Medical Sciences, Tehran, Iran
Centre of Expertise in Mycology Radboudumc/CWZ, Department of Medical Microbiology Nijmegen, Netherlands
Department of Medical Mycology/Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Department of Medical Parasitology and Mycology, School of Medicine/Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Medical Mycology and Parasitology, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background and Purpose: Candida parapsilosis is a predominant species found in nosocomial infection, particularly in hospitalized patients. The molecular epidemiology of the clinical strains of this species has not been well studied. The present study was performed with the aim of investigating the microsatellite genotyping of Candida parapsilosis among the Iranian clinical isolates. Materials and Methods: This study was conducted on ۸۱ independent clinical C. parapsilosis isolates that were genotyped by using a panel of six microsatellite markers. Results: The short tandem repeat (STR) typing of clinical C. parapsilosis isolates demonstrated ۶۸ separate genotypes, among which ۵۷ genotypes were observed once and the remaining ۱۱ cases were identified for multiple times. The Simpson’s diversity index for the panel of combined six markers yielded a diversity index of ۰.۹۹۵۱. The heterogeneity was observed among the Iranian and the Netherlands clinical C. parapsilosis isolates. Conclusion: As the findings indicated, the clinical C. parapsilosis isolates from Iran showed a high genetic diversity. It can be concluded that molecular epidemiology could be useful for screening during outbreak investigation where C. parapsilosis is involved.کلیدواژه ها
Candida parapsilosis, Genotyping, Iran, Microsatelliteاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.