zeinab Nazari - Department of Gynecology, Mazandaran University of Medical Sciences, Sari, Iran
javad Ghaffari - Pediatric Infecious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran
negar ghaffari - Mazandaran University of Medical Sciences, Sari, Iran
Fatemeh Ahangarkani - Invasive Fungi Research Center, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

Fungal agents account for the clinical manifestation of allergic disorders. The aim of the present study was to review the prevalence of hypersensitivity reactions to fungal aeroallergens in patients with allergic disorders, including allergic rhinitis, asthma, urticaria, and eczema, in Iran. The initial literature search resulted in the identification of ۵۰ records, ۲۶ cases of which met the inclusion criteria. Regarding the methods adopted for the detection of fungal allergens, serum-specific IgE and skin prick tests were used in ۶ and ۲۰ studies, respectively. Aspergillus fumigatus and Alternaria alternata sensitization was the most common allergic sensitization among the patients with allergic disorders. According to the reviewed studies, despite the humid climate of the north of Iran, fungal sensitization has a prevalence range of ۵-۷۰% in this region. In other regions, such as central and southern Iran, which have a dry and warm climate, fungal sensitization reportedly has a prevalence range of ۵-۶۵%. The prevalence of fungal sensitizations varies in different allergic disorders due to the factors related to geographic and genetic issues, gender, sample size, test operator, and assessment method.

Allergic Rhinitis, Asthma, Atopic Dermatitis, Fungus, Mold, Urticaria