Lotfollah davoodi - Antimicrobial Resistance Research Center, Communicable Diseases Institute, and Department of Infectious Diseases, Mazandaran University of Medical Sciences, Sari, Iran
Leila Faeli - Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Rogheye Mirzakhani - Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
Rozita Jalalian - Department of Cardiology, Mazandaran University of Medical Sciences, Sari, Iran
Tahereh Shokohi - Invasive Fungi Research Center(IFRC),Communicable Diseases Institute, and Department of Medical Mycology, Mazandaran University of Medical Sciences, Sari, Iran.
Firoozeh Kermani - Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Background and Purpose: Coronavirus disease ۲۰۱۹ (COVID-۱۹) and Candida prostatic valve endocarditis present various clinical manifestations which may overlap;hence, discrimination between them is extremely difficult.Case report: The case was a ۶۶-year-old man with a past medical history of mitral and aortic valves replacement one year before COVID-۱۹ co-infection. He was admitted with fever (for ۷ days), shortness of breath, cough, seizure, lethargy,headache, and ۸۵% oxygen saturation. Transesophageal echocardiography revealed multiple large-sized, highly mobile masses on both sides of the mechanical mitral valve highly suggestive of vegetation. Chest computed tomography scanning showed simulating scattered COVID-۱۹ peripheral ground-glass opacities confirmed by reverse-transcription polymerase chain reaction. The set of blood cultures yieldedyeast colonies that were identified as Candida tropicalis. The patient died of septic shock shortly after receiving antifungal therapy.Conclusion: This case emphasized the importance of early diagnosis andimplementation of antifungal treatment, particularly in patients with prosthetic cardiacvalves, to reduce their unfavorable outcomes in COVID-۱۹ patients

Candida endocarditis, case report, comorbidity, COVID-۱۹, Prosthetic valve replacement, SARS-CoV-۲, TRANSESOPHAGEAL ECHOCARDIOGRAPHY