Post-antifungal effect of the combination of anidulafungin with amphotericin B and fluconazole against fluconazolesusceptible and -resistant Candida albicans
- سال انتشار: 1401
- محل انتشار: مجله قارچ شناسی پزشکی، دوره: 8، شماره: 2
- کد COI اختصاصی: JR_CUMM-8-2_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 133
نویسندگان
Infectious and Tropical Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Medicinal Chemistry and Radiopharmacy, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Department of Microbiology, Sari Branch, Islamic Azad University, Sari, Iran
Department of Mycology, School of Medicine, Mazandaran University of Medical Science, Mazandaran, Sari, Iran.
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background and Purpose: Invasive candidiasis is a life-threatening condition that kills a large number of immunocompromised patients each year worldwide. We used postantifungal effect studies to analyze the activities of anidulafungin (AFG), as a clinically crucial antifungal drug, amphotericin B (AMB), and fluconazole (alone and in combinations) against FLC-susceptible and -resistant Candida albicans (C. albicans) isolates obtained from the cancer patients.Materials and Methods: We tested the phenomenon of post antifungal effects of FLC, AMB, AFG, and combinations of FLC+AFG, AFG+AMB, and FLC+AMB against ۱۷ C. albicans isolates obtained from the oral cavity of cancer patients. Isolates that had not been exposed to antifungals, served as a control group. Colony counts were performed at ۰, ۲, ۴, ۶, and ۲۴ h after a brief (۱ h) exposure to antifungal.Results: The FLC had no detectable post-antifungal effect independent of antifungal concentration and resembled drug-free FLC (control). Significant variations in the postantifungal effect were observed when all AMB and AFG were compared to FLC. The combination of AFG and AMB with FLC resulted in effective activity compared to FLC alone. Combination regimens were rated as indifferent in general. Interestingly, low dosages of the AFG displayed increasing fungistatic action as it approached a fungistatic endpoint against C. albicans isolates (n=۱۷).Conclusion: Our findings suggested that brief exposure to AFG, in combination with FLC and AMB, at low concentrations of the medicines utilized, could be effective in the evaluation and optimization of new dosage regimens to manage candidiasis. However, future studies will determine the clinical utility of our findings.کلیدواژه ها
anidulafungin, candida albicans, combination regimen, Post-antifungal effectاطلاعات بیشتر در مورد COI
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