Low in vitro activity of sertaconazole against clinical isolates of dermatophyte
- سال انتشار: 1399
- محل انتشار: مجله قارچ شناسی پزشکی، دوره: 6، شماره: 1
- کد COI اختصاصی: JR_CUMM-6-1_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 196
نویسندگان
Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia
چکیده
Background and Purpose: Dermatophytes are a group of fungi specialized in invading humans and other vertebrate keratinized tissues. These fungi cause a variety of skin, nail, and hair disorders, called dermatophytosis (tinea). In some cases, drug resistance to antifungals necessitates special treatment. Among the antifungal agents, sertaconazole (i.e., a third-generation imidazole) has a broad-spectrum against dermatophyte species. Regarding this, the present study was conducted to investigate the antifungal susceptibility of dermatophytes obtained from patients with dermatophytosis in Mashhad located in northeastern Iran. Materials and Methods: A total of ۷۵ clinical dermatophyte isolates, including Trichophyton mentagrophytes (n=۲۱), T. interdigitale (n=۱۸), T. tonsurans (n=۱۶), Epidermophyton floccosum (n=۱۱), Microsporum canis (n=۵), Nannizzia fulvum (n=۲), T. benhamiae (n=۱), and T. verrucosum (n=۱), were evaluated against five antifungal agents of sertaconazole, itraconazole, clotrimazole, terbinafine, and griseofulvin based on the CLSI M۳۸-A۲ guideline. Results: According to the results, the minimum inhibitory concentration (MIC) ranges of sertaconazole, terbinafine, griseofulvin, itraconazole, and clotrimazole were estimated at ۰.۱۲۵-۱۶, ۰.۰۰۲-۱, ۰.۵-۴, ۰.۰۳۱-۴, and ۰.۰۱۶-۴ μg/ml, respectively, for dermatophyte species. In addition, the geometric mean (GM) values of the MIC of sertaconazole, terbinafine, griseofulvin, itraconazole, and clotrimazole were obtained as ۳.۳۹, ۱, ۱.۴۴, ۱.۵۲, and ۱.۹۳, respectively. Conclusion: Among the tested antifungals, terbinafine and griseofulvin were the most effective agents against dermatophyte isolates. However, sertaconazole, a third-generation imidazole, did not show any significant effect. Furthermore, M. canis and E. floccosum showed the best response to the antifungal agents.کلیدواژه ها
antifungal drugs, dermatophytes, Mashhad, Microdilution, Sertaconazoleاطلاعات بیشتر در مورد COI
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