Synthesis and study of zinc (II) and copper (II) complexes with mixeddeferiprone and lamotrigine pharmaceutical ligands
- سال انتشار: 1402
- محل انتشار: بیست و دومین کنفرانس شیمی معدنی ایران
- کد COI اختصاصی: IICC22_193
- زبان مقاله: انگلیسی
- تعداد مشاهده: 41
نویسندگان
Department of Chemistry, Faculty of Chemistry, Tabriz university, Tabriz, Iran
Department of Chemistry, Faculty of Chemistry, Tabriz university, Tabriz, Iran
Department of Chemistry, Faculty of Chemistry, Tabriz university, Tabriz, Iran
چکیده
In this work, zinc (II) and copper (II) complexes with a mixture of lamotrigine (L) anddeferiprone (D) as pharmaceutical ligands with chemical formulas [Zn۲D۲L۲(OH۲)۲].(NO۳)۲ andCuDL۲.NO۳ were synthesized. The characteristics of these complexes were identifiedby infrared and ultraviolet-visible absorption spectroscopy techniques and their structurewas determined by single-crystal X-ray crystallography. The results of X-raycrystallography show that in these complexes, lamotrigine is coordinated to the centralatom as a mono dentate ligand through nitrogen atom. In the di-nucleic zinc complex, thedeferiprone ligand binds to the zinc centers through two oxygen atoms by losing the protonof the hydroxyl group. One oxygen atom is coordinated to a zinc center and the otheroxygen atom is coordinated as a bridge to both zinc atoms. Deferiprone is coordinated tothe copper atom through oxygen atoms by losing the hydrogen atom of hydroxyl groups.The metal centers have near square pyramidal coordination geometry according to thegeometrical parameter τ۵ [۱-۳].کلیدواژه ها
Lamotrigine, Deferiprone, Zinc complex, Copper complex, X-ray diffractionاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.