Poorya Hosseinabadi - Department of Environment, Faculty of Natural Resources andEnvironment, University of Birjand, Birjand, Iran
Homa Mollaei - Department of Biology, Faculty of Science, University of Birjand,Birjand, Iran
Maryam Moudi - Department of Biology, Faculty of Science, University of Birjand,Birjand, Iran
Mohammad Reza Rezaei - Department of Environment, Faculty of Natural Resources andEnvironment, University of Birjand, Birjand, Iran

Background: Melanoma is a highly aggressive skin cancerknown for its multidrug resistance, high relapse rates, and lowsurvival rates. Nanotechnology is increasingly being used inbiomedical applications worldwide, creating new alternativetreatments that can be more efficient and cost-effective whileminimizing side effects.Researchers have focused on developing new drugs and deliverymethods using nanotechnology, which has been applied tomost conventional melanoma therapies. Nano delivery of chemotherapy,targeted therapy, immunotherapy, and photodynamictherapy has been found to greatly increase treatment efficacy.Materials and Methods: In this article, data were collectedby using keywords and searching in valid databases such asGoogle Scholar, Scopus, ProQuest, and PubMed. The statisticalpopulation of this study includes all articles published until۲۰۲۳. In this research, after checking the findings and data quality,we analyzed a total of ۱۵ articles.Results: Nanofibers, produced through electrospinning, arewidely used in medication due to their small size, large surfacearea per unit mass, and porosity. Studies show that nanofibersand nanoparticles created from electrospinning devices can directand load drugs to inhibit the growth or even destroy melanomacells. Nanofibers enhance drug permeation and availability,increasing sustainability up to ۱۰ days.PCL-Fe۳O۴ nanofiber-based bandages have been found to beeffective in treating skin cancer. However, solvents used inexisting techniques can be harmful and may interfere with thedrug's effectiveness.Conclusion: Further research is needed to explore how nanofiberscan be integrated with other drug delivery systems such asnanoparticles to maximize drug output to the skin. Nanofibersare currently underused as a local transmission system, but theyoffer promising possibilities as a drug delivery system in skincancer treatment.Although nanofiber-based treatments for cancer cells offer significantbenefits compared to traditional chemotherapy, the useof harmful solvents can compromise their effectiveness. Thesesolvents have the potential to interfere with the drug's intendedpurpose and undermine its therapeutic value

Electrospinning, nanofibers, drug delivery, skin cancer