Bioinformatic prediction of miRNAs targetingCCND۱; An approach toward breast cancer therapy

سال انتشار: 1402
محل انتشار: اولین کنگره بین المللی ژنومیک سرطان
کد COI اختصاصی: CGC01_262
زبان مقاله: انگلیسی
تعداد مشاهده: 49

نویسندگان

Department of Genetics, Faculty of Biological sciences ,TarbiatModares University,Tehran

چکیده

Background: Bioinformatics software are tools designed toextract meaningful information from molecular-biological biology databases and perform sequencing. MicroRNAs (miRNAs)are endogenous small RNAs with diverse functions and play arole in many metabolic and signaling pathways. Dysregulationof miRNAs is a common characteristic of many cancers. As anoncogene, CCND۱ plays a key role in promoting breast cancer.Therefore, identification of miRNAs involved in the regulationof CCND۱ would be useful in finding a treatment approach forbreast cancer.Materials and Methods: The miRtargetlink and targetscandatabases were used to determine miRNAs that interact withCCND۱. The interaction of each predicted miRNAs withCCND۱ ۳´UTR was analyzed by RNAhybrid. Finally, DianamiRpathv۳ was used to find the metabolic and signaling pathwaysrelated to these miRNAs.Results: After analyzing among the miRNAs predicted forCCND۱ by RNAhybrid, three miRNAs that showed a strongerrelationship with CCND۱ were selected, which are hsa-miR-۱۰۶a, hsa-miR-۱۹۳a, hsa-miR-۱۵a. According to the data obtainedfrom Diana tools, a strong relationship between hsamir-۲۰a-۵p and hsa-mir-۱۷-۵p was observed in the signalingpathways (e.g. TGFβ) in cancer.Conclusion: Studies have shown that high expression ofCCND۱ is associated with breast tumor progression. As thehigh expression of CCND۱ is associated with a decrease in thelife expectancy of breast cancer patients, expression modulationof miRNAs mentioned above can be a therapeutic approach toprevent the progression of breast cancer.

کلیدواژه ها

Breast Cancer, CCND۱, MicroRNAs

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.