Mohammad Faraji-Rad - Department of Neurosurgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mehdi Khajavi - Department of Neurosurgery, Emdad Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Hassan Arjmand - Department of Surgery, Ghaem Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Esmat Shajari - Department of Neurosurgery, Ghaem Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Daryoush Hamidi Alamdari - Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Background: Gliomas are the most common primary brain tumors of the central nervous system. Among a number of different bio-molecular events, molecular connections between oxidative stress pathways and their development is prevalent. Oxidative stress is the consequence of an imbalance between pro-oxidant factors and antioxidant defense. This imbalance may lead to DNA damage and changes in growth and function of cells in the brain. Many evidences show that reactive oxygen species in the mammalian brain are directly responsible for cell and tissue function and dysfunction. A brain tumor is correlated with oxidative stress. In this study, we determine the pro-oxidant – antioxidant balance in patients with grade IV brain tumors (glioblastoma multiforme) by the pro-oxidant – antioxidant assay.Methods: We collected sera from ۵۰ patients with high grade (IV) glioblastoma multiform and ۴۹ healthy subjects. The pro-oxidant - antioxidant assay was measured.Results: There was a significant increase in pro-oxidant - antioxidant values in patients (۱۵۸.۱۰±۸۵.۷۱ HK unit) compared to the control group (۷۴.۵۴±۳۳.۵۴ HK; P=۰.۰۰۱.Conclusion: The pro-oxidant - antioxidant balance assay can show a high level of pro-oxidants in the sera of patients with glioblastoma which indicates the presence of oxidative stress in this group.