Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran after Implementation of the Neo-adjuvant Chemo-radiation: Retrospective Cohort Study
- سال انتشار: 1400
- محل انتشار: مجله سرطان خاورمیانه، دوره: 12، شماره: 4
- کد COI اختصاصی: JR_MISJ-12-4_010
- زبان مقاله: انگلیسی
- تعداد مشاهده: 73
نویسندگان
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, Iran
Faculty of Social Sciences, Tampere University, Tampere, Finland
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, Iran
Department of Surgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, Iran
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, Iran
Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, Iran
Cancer Biology Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, Iran
چکیده
Background: Iran is a high-risk area with a poor prognosis for esophageal cancer. We conducted the present study to evaluate the survival rate of esophageal cancer after the introduction of neo-adjuvant chemo-radiation at the Cancer Institute of Iran. Method: We performed a retrospective cohort study and abstracted the data of ۴۲۱ patients who referred to the Cancer Institute of Iran between ۲۰۰۷ and ۲۰۱۱. Life table and Kaplan-Meier approaches were applied to estimate ۱-, ۳-, and ۵-year survival rates and corresponding ۹۵% confidence intervals (CI). Multiple Cox regression model was recruited for investigating the association between ۵-year survival rate and prognostic factors. Results: We found that ۱-, ۳-, and ۵-year survival rates were ۶۶.۷%, ۲۸.۲, and ۲۰.۹%, respectively. The hazard ratio (HR) was significantly higher among the patients who has received definitive chemo-radiation therapy (Hazard ratio (HR) = ۲.۲, ۹۵% confidence interval (CI): ۱.۱, ۴.۲), surgery (HR= ۲.۰ ۹۵% CI: ۱.۰, ۳.۷), and palliative care (HR= ۴.۲, ۹۵% CI: ۲.۱, ۱.۸) compared with those who received neo-adjuvant chemo-radiation and surgery. We also found that the ۵-year survival rate was doubled in the current study conducted between ۲۰۰۷ and ۲۰۱۱ (۲۰.۹%) compared with the previous one conducted between ۱۹۹۷ and ۲۰۰۶ (۱۰.۰%). Additionally, a considerable improvement was observed in ۱- and ۳-year survival rate of esophageal cancer at the Cancer Institute of Iran. Conclusion: Following the administration of neo-adjuvant chemo-radiation therapy, the prognosis of esophageal cancer has improved significantly at the Cancer Institute of Iran during the last decade. More data from other cancer centers and provinces of Iran are required.کلیدواژه ها
Esophagus, Neoplasms, staging, Chemoradiation, Survivalاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.