Mojtaba Omidvar - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Sedigheh Tahmasebi - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Majid Akrami - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Payam Arasteh - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Vahid Zangouri - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Akbar Safaei - Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
Sara Hosseini - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Aida Salehi Nobandegani - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Seyed Morteza Hosseini - Non-communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
Abdolrasoul Talei - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Background: Much is still unknown regarding the clinicopathology and prognosis of patients with multifocal/multicentric breast cancer (MMBC). We herein compared the clinicopathology and prognosis of patients with unifocal and MMBCs.Method: This cross-sectional research is a part of Shiraz Breast Cancer Registry (SBCR). We studied all the patients in the SBCR (n=۶۱۴۵). Ultrasound reports were used to differentiate between MMBCs and unifocal breast cancers (BCs). All the patients were examined with mammography and the diagnosis was confirmed postoperatively via pathology reports.Results: After exclusion, ۴۰۴۵ patients entered the study (n=۱۰۷۲ and n=۲۹۷۳ for multifocal/multicentric and unifocal BCs, respectively). The mean follow-up period was ۵۷.۹ (۰.۲۷-۲۷۵) months. Patients with MMBCs had higher rates of mastectomy (۴۸% vs. ۴۰.۱%; P < ۰.۰۰۱) and higher rates of HER-۲ overexpression (۳۲.۱% vs. ۲۶%; P = ۰.۰۰۱) compared with those with unifocal BCs. Tumor size, lymph node involvement, type of axillary management, chemotherapy, radiotherapy, hormonal therapy, recurrence rates, histological grade, lymphovascular invasion, axillary node involvement, estrogen and progesterone receptor expression status, tumor, node, and metastasis staging were not significantly different between the groups. Five-year overall survival was ۸۸.۳% and ۸۹% (P = ۰.۸) for unifocal and MMBCs, respectively; moreover, five-year disease-free survival was ۸۰.۲% and ۸۱.۲% (P = ۰.۴۱), respectively.Conclusion: Despite the controversy regarding prognosis and surgical management in MMBCs, we found that MMBCs had similar clinicopathological features and prognosis compared to unifocal BCs. Survival, recurrence, and metastasis were similar among the two groups.

Breast Neoplasm, staging, Survival, Multicentricity, Multifocality