Vitamin D Serum Levels in Oral Lichen Planus and Oral Cancer Patients
- سال انتشار: 1402
- محل انتشار: مجله سرطان خاورمیانه، دوره: 14، شماره: 4
- کد COI اختصاصی: JR_MISJ-14-4_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 69
نویسندگان
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Otolaryngology Research Center, Department of Otolaryngology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: This study aimed to evaluate serum vitamin D levels in patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in comparison to healthy controls in an Iranian population. Method: A cross-sectional study was conducted, which included ۶۹ patients with OLP, ۴۰ patients with OSCC, and ۶۰ healthy controls. Serum vitamin D levels were measured using the ELISA method. The data were analyzed using Mann-Whitney and T-tests, and statistical significance was set at P < ۰.۰۵. Results: The study found that ۱۷.۹% of OLP patients, ۲۷.۲۵% of OSCC patients, and ۲۵% of the control group had normal vitamin D levels. The mean vitamin D level in OLP patients (۱۷.۰۰ ± ۱۴.۱۶ ng/mL) was significantly lower than that in the control group (۲۲.۹۹ ± ۱۴.۴۶ ng/mL) (P = ۰.۰۰۳). However, in OSCC patients, the mean vitamin D level (۲۴.۶۳ ± ۱۶.۱۹ ng/mL) was not significantly different from that of the control group. Conclusion: The study revealed a high rate of vitamin D deficiency and insufficiency in OLP, OSCC, and control group patients. Vitamin D deficiency was more common in patients with OLP. Vitamin D deficiency may potentially increase the risk of OLP and OSCC development and progression.کلیدواژه ها
Neoplasms, Lichen planus, Oral, Vitamin D, serumاطلاعات بیشتر در مورد COI
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