Assessment of the Relationship between Human Papilloma Virus Infections and Cutaneous Squamous Cell Carcinoma

  • سال انتشار: 1399
  • محل انتشار: مجله سرطان خاورمیانه، دوره: 11، شماره: 2
  • کد COI اختصاصی: JR_MISJ-11-2_007
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 149
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نویسندگان

Mohammad Javad Yazdanpanah

Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Noorieh Sharifi Sistani

Department of Pathology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Elnaz Hosseini

Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Elham Vosoughi

Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Seyed Saeid Hosseini

Department of Otorhinolaryngology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Khajedaluee

Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran

Saeid Amel Jamehdar

Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

چکیده

Background: The relationship between HPV infection and skin squamous cell carcinoma (SCC) development in immunocompetent individuals is unclear. Therefore, the purpose of this study was to assess the association between HPV infection and skin SCC. Methods: HPV DNA prevalence was evaluated in the paraffin embedded specimens of ۷۰ immunocompetent patients, of which ۳۵ patients had skin SCC and ۳۵ had normal skin. PCR technique and GP۶/۵ primers were utilized for HPV DNA detection. Result: Based on this study, ۱۴.۳% of the cases (۵ of ۳۵, ۲ with low risk and ۳ with high risk viruses) and ۲.۹% of the controls (۱ of ۳۵ with low risk virus) had papilloma viruses. However, there was no significant statistical relationship between the HPV DNA presence and the SCC development in skin. Conclusion: The direct effect of HPV on skin cancerogenesis remains questionable.

کلیدواژه ها

Human papilloma virus, Non-melanoma skin cancers, Squamous cell carcinoma

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