Babak Abdolkarimi - Department of Pediatric Hematology and Oncology, Lorestan University of Medical Sciences, Khoramabad, Iran
Aarash Alghasi - Department of Pediatric Hematology and Oncology, Ahvaz University of Medical Science, Ahvaz, Iran
Mona Moeini - Mahak Pediatric Cancer Center, Tehran, Iran
Mozhgan Hashemieh - Department of Pediatric Hematology and Oncology, Shahid Beheshti University of Medical Science, Tehran, Iran
Shahab Forutani - General Physician, Lorestan University of Medical Sciences, Khoramabad, Iran

Neuroblastoma is an extracranial solid tumor that is most commonly observed in children, yet it is rare to have brain metastasis in neuroblastoma during primary involvement or relapse. In this article, we report a successful treatment of high risk neuroblastoma with primary leptomeningeal metastasis based on developing countries facilities and explain combination chemotherapy (a classic regimen with salvage regimen based on temozolamid and methotroxate intratechal chemotherapy and localized radiation therapy) as a multimodal therapy.

Neuroblastoma, Brain metastasis, Leptomeningeal metastasis