Effect of Oral Cryotherapy on Combination Chemotherapy-induced Oral Mucositis: A Randomized Clinical Trial
- سال انتشار: 1391
- محل انتشار: مجله سرطان خاورمیانه، دوره: 3، شماره: 2
- کد COI اختصاصی: JR_MISJ-3-2_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 163
نویسندگان
Department of Medical Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Surgical Nursing, Iranshahr School of Nursing and Midwifery, Zahedan University of Medical Sciences, Iranshahr, Iran
Department of Oncology/Radiotherapy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: This study assesses the effect of oral cryotherapy on the incidence and severity of chemotherapy-induced oral mucositis in combined chemotherapy regimens.Methods: This was a randomized controlled trial that enrolled ۸۰ cancer patients. We evaluated the primary oral status of all patients prior to chemotherapy. Patients were divided into two groups, experimental and control. The experimental group was given ice to place in their mouths from ۵ min before to ۵ min after chemotherapy.The control group received no intervention. Both groups were treated with the following chemotherapy regimens: i) ۵- fluorouracil + leucovorin; ii) cyclophosphamide + adriamycin + ۵-fluorouracil; or iii) cyclophosphamide + methotrexate + fluorouracil. World Health Organization and patient-based oral mucositis scales were used for evaluation.Results: According to the WHO based Oral Mucositis Scale, the incidence of oral mucositis in the intervention group (۴۵%) was significantly lower than the control group (۷۷.۵%; P=۰.۰۱). The incidence of oral mucositis in the intervention group based on the Patient-Judged Oral Mucositis Scale was lower than the control group. The findings of this study indicated that patients who underwent cryotherapy had less severe oral mucositis based on both WHO (P=۰.۰۱) and patient oral mucositis scales (P=۰.۰۰۱).Conclusion: Oral cryotherapy because of its ease of application, tolerability and lack of side effects makes it an important resource for reducing the incidence and severity of oral mucositis. The role of oncology nurses is crucial to the application and success of oral cryotherapy.کلیدواژه ها
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.