Unique Variant Complex Chromosome Translocation in Myeloid Leukemia: Report of a Case and Literature Review

  • سال انتشار: 1391
  • محل انتشار: مجله سرطان خاورمیانه، دوره: 3، شماره: 2
  • کد COI اختصاصی: JR_MISJ-3-2_008
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 133
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نویسندگان

Abolfazl Movafagh

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mehrdad Hashemi

Associate professor of Molecular Genetics, Department of Genetics, Islamic Azad University,Tehran Medical Branch,Tehran,Iran

Mojtaba Ghadiani

Department of Internal Medicine/Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Reza Mirfakhraei

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hossein Darvish

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Davood Zare Abdollahi

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hamid Ghaedi

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Shamsi Safari

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Leyla HaghNejad

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Sara Mosammami

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Niloofar Safavi Naeini

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Ramin Miri

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mostafa Rezaei Tavirani

Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

چکیده

Background: According to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. This study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations.Methods:We conducted a web-based search for all peer review articles published on the subject of complex chromosome tranlsocations in chronic and acute myeloid leukemia in MEDLINE, PubMed and Mitelman (http://cgapanci.nih.gov/ chromosomes/Mitelman) databases in addition to other pertinent web references. In addition, we performed conventional cytogenetic studies of ۲۴- to ۷۲-h cultures on bone marrow/peripheral blood cells obtained from the current case. Cells were finally treated by the giemsa-trypsin-giemsa banding technique.Results: The result of this case revealed an abnormal karyotype that had a novel complex translocation which involved chromosomes ۲, ۵, ۹, and ۲۲. We performed karyotyping after the initiation of chemotherapy. Karyotyping results showed a complex karyotype ۴۶,XX,t(۹;۲۲;۲;۵).Conclusion: This study discusses a case of chronic myeloid leukemia with complex chromosome translocations and may provide novel information regarding these translocations in leukemias.

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