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Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma

عنوان مقاله: Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma
شناسه ملی مقاله: JR_MISJ-3-2_009
منتشر شده در در سال 1391
مشخصات نویسندگان مقاله:

Mehdi Dehghani - Shiraz University of Medical Sciences, Hematology Research Center, Shiraz, Iran
Vahid Mohammad Karimi - Shiraz University of Medical Sciences, Hematology Research Center, Shiraz, Iran

خلاصه مقاله:
We report a case of multiple myeloma that presented with anorexia, fatigue, high erythrocyte sedimentation rate, bone marrow plasmacytosis of more than ۳۰%, polyuria,and low urine specific gravity. This unusual presentation was diagnosed as nephrogenic diabetes insipidus secondary to a proximal tubular dysfunction. The tubular functional disturbance appeared to be related to the presence of lambda-type light chains. The patient was treated with desmopressine without response. After one month of treatment with thalidomide and dexamethasone for myeloma there was a dramatic response with decreased urine output.

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1818918/