Protective effects of Nigella sativa on synaptic plasticity impairment induced by lipopolysaccharide
- سال انتشار: 1397
- محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 9، شماره: 1
- کد COI اختصاصی: JR_VRFAN-9-1_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 80
نویسندگان
Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
Department of Physiology, Esfarayan Faculty of Medical Sciences, Esfarayan, Iran
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
In the present study the protective effect of Nigella sativa (N. sativa)on synaptic plasticity impairment induced by lipopolysaccharide (LPS) in rats was investigated. Fifty-eight rats were grouped and treated as follows: ۱) control (saline), ۲) LPS, ۳) LPS-N. sativa,and ۴) N. sativa. In a Morris water maze test, the escape latency and traveled path to find the platform as well as time spent and the traveled distance in target quadrant (Q۱) were measured. Long term potentiation (LTP) from CA۱ area of hippocampus followed by high frequency stimulation to Schafer collateral was studied and slope, slope ۱۰-۹۰% and amplitude of field excitatory field potential (fEPSP) were calculated. The escape latency and traveled path in LPS group were significantly higher than those in the control group while, in LPS-N. sativa group these parameters were significantly lower than those in LPS group. The rats in LPS group spent less time and traveled shorter distance in Q۱ than the rats in the control group while, in LPS-N. sativa group the rats spent more time and traveled longer distance than the rats in LPS group. LPS significantly decreased slope, slope ۱۰-۹۰% and amplitude of fEPSP while, in LPS-N. sativa group these parameters increased compared to LPS group. The results indicated that the hydro-alcohol extract of N. sativa protected against synaptic plasticity and spatial learning and memory impairment induced by LPS in rats.کلیدواژه ها
Lipopolysaccharide, Long term potentiation, Nigella sativa L, Spatial memory, Synaptic plasticityاطلاعات بیشتر در مورد COI
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