Therapeutic effects of marshmallow (Althaea officinalis L.) extract on plasma biochemical parameters of common carp infected with Aeromonas hydrophila

  • سال انتشار: 1396
  • محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 8، شماره: 2
  • کد COI اختصاصی: JR_VRFAN-8-2_010
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 170
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نویسندگان

Mahdi Banaee

Department of Aquaculture, Faculty of Environment and Natural Resources, Behbahan Khatam Al-Anbia University of Technology, Behbahan, Iran

Vahid Soleimany

Department of Aquaculture, Faculty of Environment and Natural Resources, Behbahan Khatam Al-Anbia University of Technology, Behbahan, Iran

Behzad Nematdoost Haghi

Department of Aquaculture, Faculty of Environment and Natural Resources, Behbahan Khatam Al-Anbia University of Technology, Behbahan, Iran

چکیده

This study evaluated preclinical and clinical safety of marshmallow (Althaea officinalis L.) extract as a naturopathic medicine in common carp deliberately infected with Aeromonas hydrophila. The fish were fed ۰ (control), ۲.۵۰, ۵.۰۰ and ۱۰.۰۰ g of marshmallow extract for ۶۰ days in a preclinical experiment and then, challenged with A. hydrophila for a ۱۰-day experiment. Significant increases were observed in aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), creatine phosphokinase (CPK) activities and plasma creatinine levels in fish fed ۱۰ g marshmallow extract per kg feed. However, alanine aminotransferase (ALT) significantly decreased on day ۶۰. The fish fed ۲.۵۰ g marshmallow extract per kg feed indicated increased levels of total protein and globulin. There were no significant changes in albumin levels (p > ۰.۰۵). ۲.۵۰ and ۵.۰۰ g marshmallow significantly decreased triglyceride and cholesterol levels and increased glucose levels (p < ۰.۰۵). A. hydrophila significantly increased AST, ALT, LDH, ALP and CPK activities and plasma glucose, cholesterol, triglycerides and creatinine levels after ۱۰ days (p < ۰.۰۵). Total plasma protein, albumin and globulin levels in fish challenged with A. hydrophila were significantly lower than the control group (p < ۰.۰۵). Marshmallow extract at ۵.۰۰ and ۱۰.۰۰ g can adjust plasma biochemical parameters in fish challenged with A. hydrophila. The results of preclinical studies and pharmaceutical toxicity of marshmallow extract revealed that dietary levels lower than ۵.۰۰ g were safe and effective. The results of this clinical study demonstrated that marshmallow extract (۵.۰۰ g kg-۱ feed) can protect fish against A. hydrophila.

کلیدواژه ها

Aeromonas hydrophila, Biochemical parameters, Common carp, Marshmallow

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