Changes of stress oxidative enzymes in rat mammary tissue, blood and milk after experimental mastitis induced by E. coli lipopolysaccharide
- سال انتشار: 1394
- محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 6، شماره: 2
- کد COI اختصاصی: JR_VRFAN-6-2_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 103
نویسندگان
Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
چکیده
The present study investigated the effects of E. coli lipopolysaccharide (LPS) induced mastitis model in rat on the activity of antioxidant enzyme systems. To achieve this purpose, E. coli LPS were infused into the mammary gland of ۱۲ rats ۷۲ hr postpartum and compared with ۱۲ rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. The antioxidant activities of the enzymes, superoxide dismutase, glutathione peroxidase, and catalase together with malondialdehyde (MDA) level were assayed in blood serum, milk and mammary tissue. Results obtained showed that, the antioxidant enzyme activities in milk, blood serum and mammary tissue were significantly decreased while the level of MDA, the indicator of lipid peroxidation were significantly increased following intramammary inoculation of LPS compared to the control animals. Histopathological examination also revealed the infiltration of inflammatory cells in mammary tissue and disruption of acinar structure and acinar lumina in mastitic rats. The results indicated that LPS-induced mastitis could alter antioxidant enzymes and increase lipid peroxidation.کلیدواژه ها
Antioxidant enzymes, Lipopolysaccharide, malondialdehyde, Mastitis, Ratاطلاعات بیشتر در مورد COI
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