Detection of Arctic and European cluster of canine distemper virus in north and center of Iran
- سال انتشار: 1394
- محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 6، شماره: 3
- کد COI اختصاصی: JR_VRFAN-6-3_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 58
نویسندگان
Department of Environmental Sciences, Faculty of fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Tasnim Biotechnology Research Center, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Department of Microbiology, Islamic Azad University of Qom Branch, Qom, Iran
چکیده
Canine distemper virus (CDV) creates a very contagious viral multi-systemic canine distemper (CD) disease that affects most species of Carnivora order. The virus is genetically heterogeneous, particularly in section of the hemagglutinin (H) gene. Sequence analysis of the H gene can be useful to investigate distinction of various lineages related to geographical distribution and CDV molecular epidemiology. Since vaccination program is conducted only in large cities of Iran, CD still remains as one of the major causes of death in dogs in this country. In order to monitor H gene, CDV has been detected in ۱۴ out of ۱۹ sampled dogs through the amplification of nucleoprotein (NP) gene in nested-PCR assay. In the next step ۶۶۵ bp of H gene was amplified in ۹ out of ۱۴ NP-gene positive dogs. Phylogenetic analysis distinguished two distinct CDV genotypes in Iran. JN۹۴۱۲۳۸ has been embedded in European cluster and JN۹۴۱۲۳۹ has been embedded in Arctic cluster. Nucleic analysis has been shown high difference among both Iranian CDV lineages with CDV vaccine strains.کلیدواژه ها
Canine distemper virus, Hemagglutinin gene, Nucleoprotein gene, Phylogenetic analysisاطلاعات بیشتر در مورد COI
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