Effects of Hydro-Alcoholic Leaf Extract of Kardeh (Biarum Bovei Blume) on the Blood Glucose and Lipid Peroxidation in Cerebral Tissues and Lipid Profile in Streptozotocin Induced Diabetic Rats

  • سال انتشار: 1394
  • محل انتشار: مجله دیابت و چاقی ایران، دوره: 8، شماره: 1
  • کد COI اختصاصی: JR_IJDO-8-1_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 103
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نویسندگان

Zohre Valizadeh

Assistant Professor Department of Nursing and Midwifery, Faculty of Nursing and Midwifery, Dezful Branch, Islamic Azad University, Dezful, Iran

Maryam Rafieirad

Assistant Professor Department of Biology, Faculty of Sciences, Islamic Azad University, Izeh Branch, Izeh, Iran

چکیده

Objective: Oxidative stress is the result of an imbalance between free radical production and antioxidant defenses of the body. The use of antioxidants can have preventive effects in diabetes. The present study aims to show the effects of Biarum Bovei extracts on lipid profile, lipid peroxidation in streptozocin induced diabetic male rats. Materials and Methods: Animals were randomly assigned to the control group, diabetic with streptozotocin (STZ ۶۰ mg/kg) and ۵ diabetic groups rats which have received hydro-alcoholic extract Biarum Bovei (۵۰, ۱۰۰, ۲۰۰, ۴۰۰, ۸۰۰ mg/kg) via gavages for two weeks. Blood glucose, serum lipid profile and malondialdehyde (MDA) in brain tissue were measured at the end of experiment. Results: The results indicate that blood glucose in diabetic group increased significantly (P< ۰.۰۰۰۱) in comparison with the control group. Biarum Bovei extract at a dose (۱۰۰ and ۲۰۰ mg/kg), causing a significant decrease in blood glucose levels (P< ۰.۰۱). The MDA significantly decreased in the hippocampus in the group receiving ۱۰۰, ۲۰۰ mg/kg Biarum Bovei extract (P< ۰.۰۰۱, P< ۰.۰۱) respectively. Conclusion: Hydro-alcoholic extract of Biarum Bovei may have antioxidant properties which reduce blood glucose and complications of diabetes such as lipid peroxidation and lipid profiles. It can be used from this plant to improve diabetes along with medication.

کلیدواژه ها

Biarum Bovei, Blood glucose, Lipid peroxidation.

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