Propofol Unveiled: A Novel Approach to Inducing Diabetes in Wistar Rats

  • سال انتشار: 1402
  • محل انتشار: اولین کنفرانس بین المللی و چهارمین کنفرانس ملی تجهیزات و فناوری های آزمایشگاهی
  • کد COI اختصاصی: IMTC04_057
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 168
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نویسندگان

Hamidreza Golian

Department of Biotechnology, Faculty of Sciences and Advanced Technologies in Biology Majors, University of Science and Culture, Tehran, Iran

Mehrshad Mirdar-Soltani

Department of Biotechnology, Faculty of Sciences and Advanced Technologies in Biology Majors, University of Science and Culture, Tehran, Iran

Tannaz Hamami

Department of Toxicology, Faculty of Medical Sciences and Pharmacy, University of Tehran, Tehran, Iran

Sara Heidari

Department of Biotechnology, Faculty of Biological Sciences, University of Kharazmi, Karaj, Iran

Shilan Nasri

Department of Life Science Engineering, Faculty of New Sciences and Advanced Technologies, University of Tehran, Tehran, Iran

چکیده

Alloxan and streptozotocin are commonly used to induce diabetes in animal models. They destroy pancreaticbeta cells through different mechanisms. However, their limitations include laboratory toxicity andlow efficacy at high doses. Combining a new generation of diabetes-inducing agents with propofol offersimproved efficiency, effectiveness, and cost-effectiveness. Both substances cause diabetes by generatingreactive oxygen species, but the source of these radicals differs. Alloxan and its reduced product, dialuricacid, create superoxide radicals, leading to pancreatic tissue damage. Streptozotocin enters beta cellsthrough GLUT۲ and induces DNA alkylation, depleting NAD+ and ATP levels, and increasing xanthineoxidase enzyme activity. Propofol intensifies the defects caused by the other substances, triggering nervepathways that inhibit repair and producing free radicals, which damage the pancreas. In the study, alloxan,streptozotocin, and propofol induced diabetes in ۴۰ Wistar laboratory rats, resulting in hyperglycemia andreduced insulin secretion.

کلیدواژه ها

Propofol, Alloxan, Streptozotocin, Diabetes, Pancreatic Beta Cells.

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